Abstract In this paper, a conception of general time-frequency domain 2-Dirnensional Spread Spectrum (2DSS) is proposed. The principles of the transmitter and receiver of the 2DSS communications for additive white Gaussian noise channels are discussed, the Bit Error Rate (BER) of this scheme is also analyzed. The simulation result of the BER of the 2DSS communications is provided. It shows that the simulation result and analyzed result are almost the same.