Abstract：Traditionally, skin permeability evaluation, which is realized by impedance detected at a certain frequency based on macro electrodes, has the disadvantages of large measurement error, low sensitivity and difficulty in integration. In order to resolve this problem, a flexible non-symmetric interdigital microsensor is designed by analyzing the layered structure of skin and the relationship between skin permeability and impedance of Stratum Corneum(SC). The impedance of SC is measured and analyzed based on the RCW-layered impedance model. It is illustrated that the impedance magnitude of microsensor output and model fitting parameters can be used as the important indicators to evaluate skin permeability. It is proved that the developed sensor can be applied to distinguishing the different individuals’ skin permeability, and it strongly supports the adjustment of wearable devices related to human physiological and biochemical detection.
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